Sv. Urologi nr 1 2017 - Svensk Urologisk Förening


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Ku70 and Ku80 make up the Ku70/80 heterodimer. They are encoded by the Xrcc5 and Xrcc6 genes, respectively, and are highly abundant in both prokaryotes and eukaryotes. The stability of these proteins depends on each other. The nuclear DNA repair protein Ku70/80 is a tumor-associated antigen displaying rapid receptor mediated endocytosis. / Fransson, Johan; Borrebaeck, Carl..

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2008 Nov;20(11):1978-85. doi: 10.1016/j.cellsig.2008.07.006. Epub 2008 Jul 10. Authors Takuya Abe 1 Recombinant Human Ku70 & Ku80 Heterodimer Protein (Met1-Ile732 & Met1-Asp609) CT018-H07B with a fusion His Tag, is expressed in Baculovirus-Insect Cells. With high purity, high biological activity, high stability, and other superior features, you can use this Human Ku70 & Ku80 Heterodimer protein for relevant bioassay and related research.

sCLU  Monoclonal Antibody for studying Ku70 in the Cell Cycle / Checkpoint research Ku is a heterodimeric protein composed of two subunits (Ku70 and Ku80)  Ku70 & Ku80 Heterodimer Proteins Research Reagents. Ku is a heterodimer of two proteins termed Ku70 (69kDa, encoded by the XRCC6 gene) and Ku80 (  Ku genes play a key role in the non-homologous end-joining pathway.

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Identification of poly(ADP-ribose) polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expression2006Ingår i: BMC Molecular Biology,  SWISSPROT:Q9UK80 ENSP00000289865 ENSG00000143258 ensHS ens ENSP00000300145 ENSG00000166896 ensHS ens Ku70-binding protein 3. KU70 — Kontrolluppgift 2017 Näringsbidrag och royalty. KU72 — Kontrolluppgift KU80 — Kontrolluppgift — Betalning från utlandet.

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Kontrolluppgiften (KU25 och KU70) och den månatliga arbetsgivardeklarationen på individnivå  7 SAMPLE FILE INCOME STATEMENTS INTERESTS DIVIDENDS ETC. (KU20-25, KU30-41, KU30-50, KU71-72, KU80-81) FOR. BANKS ETC. Levereras Livslängd: 70 000 h/L80/B10 Ta 25°C. med 2 m sladdställ och 2 m fri x 45 mm 4000 K U 70 150 83 LED-panel 40W prismatisk DALI Vit 4000 lm 595  Månadsbeloppet för Unnis sammanlagda pension blir då 80. 724/12 = 6 727 Dessa är bland annat betald ränta (KU25) och näringsbidrag (KU70).

We developed a novel assay to measure DNA binding and release kinetics using differences in Förster resonance energy transfer (FRET) of the ECFP-Ku70/EYFP-Ku80 heterodimer in soluble and DNA end bound states. Double strand break (DSB) recognition is the first step in the DSB damage response and involves activation of ataxia telangiectasia-mutated (ATM) and phosphorylation of targets such as p53 to trigger cell cycle arrest, DNA repair, or apoptosis. It was reported that activation of ATM- and Rad3-related (ATR) kinase by DSBs also occurs in an ATM-dependent manner. On the other hand, Ku70/80 is The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage. Reynolds P(1), Anderson JA, Harper JV, Hill MA, Botchway SW, Parker AW, O'Neill P. Author information: (1)Department of Oncology, Gray Institute for Radiation Oncology & Biology, University of Oxford, Oxford OX3 7DQ, UK. The Ku70/80 complex recognizes DNA breaks and serves as an essential hub for recruitment of NHEJ components. Here, we describe intramolecular interactions of the Ku70 C-terminal domain, known as the SAP domain.
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Classification: RNA BINDING PROTEIN; Organism(s):  The Ku70/80 heterodimer is a key-player in the NHEJ pathway and binds to DNA termini with high affinity, where it helps to protect DNA ends from degradation  6 Oct 2020 Knockdown of Ku70 or Ku80 in naïve mice elicited mitochondrial collapse or ER stress, leading to bronchial epithelial cell apoptosis and  25 Jun 2020 During DSB repair by NHEJ, Ku70 plays a key role in conjunction with Ku80 to form the Ku70–Ku80 heterodimer.

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Here, we describe intramolecular interactions of the Ku70 C-terminal domain, known as the SAP domain. Using single-particle cryo-electron microscopy, mass spectrometric analysis of intermolecular crosslinking and molecular modelling The heterodimer, Ku70/80, is an early player in DSB repair and is part of the non-homologous end joining (NHEJ) repair pathway.

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